A woman known as The Nurse runs a high-security, members-only hospital for high-rolling criminals in Los Angeles. When a bank robber brings his injured teammates along with $18 million in jewels there, a mob boss and the police both follow. With the hospital under siege, The Nurse, her orderly (Dave Bautista) and her other criminal patients have to defend themselves from outside threats as well as inside backstabbers who want to gain possession of the jewels.