In The Last Son, murderous outlaw Isaac LeMay hears a prophecy that predicts he will be murdered by one of his sons. Determined to overcome this, LeMay sets out to find his sons and kill them himself. Pursued by bounty hunters and Sheriff Solomon, Isaac begins his hunt. But one son, Cal, is on a killing rampage of his own. When the two meet, a deadly game of cat-and-mouse ensues.